Medical Hair Restoration

Medical Hair Restoration
Medical hair restoration in​ the​ literal sense includes the​ hair loss treatment which depends upon the​ use of​ medicines. Unusual hair loss both in​ men and women is​ caused by the​ alterations in​ the​ androgen metabolism. the​ metabolism of​ androgen involves an enzyme called 5 alpha reductase which combines with the​ hormone androgen testosterone to​ form the​ DHT Dihydrotestosterone. DHT is​ a​ natural metabolite of​ our body which is​ the​ root cause of​ hair loss.
DHT gets into the​ hair follicles and roots dermal papilla,​ it​ prevents necessary proteins,​ vitamins and minerals from providing nourishment for​ hair follicles. This shortens their growing stage anagen phase and lengthens their resting stage telogen phase of​ the​ follicle. DHT is​ responsible for​ 95% of​ hair loss.
Some individuals both men and women are genetically predisposed to​ produce more DHT than the​ normal individuals. DHT also creates a​ waxlike substance around the​ hair roots. DHT accumulation inside the​ hair follicles and roots is​ one of​ the​ primary causes of​ male and female pattern hair loss.
Blocking the​ synthesis of​ DHT at​ molecular level forms the​ basis for​ the​ treatment of​ MPHL male pattern hair loss and FPHL female pattern hair loss. There are many natural DHT blockers and a​ number of​ ​Drug​s which are used for​ medical hair restoration. Let’s see.
Minoxidil has the​ distinction of​ the​ first ​Drug​ being used for​ promoting the​ hair restoration. Minoxidil was then approved as​ medical hair restoration treatment ​Drug​ for​ men by the​ FDA,​ USA in​ 1988 as​ a​ 2% solution,​ followed by 5% solution in​ 1997. for​ women,​ the​ 2% solution was approved in​ 1991. Though 5% solution is​ not approved for​ women,​ it​ is​ used as​ a​ medical hair restoration treatment by many dermatologists worldwide.
Mechanism of​ action
Minoxidil is​ thought to​ have a​ direct mitogenic effect on​ epidermal cells. Calcium normally enhances epidermal growth factors to​ inhibit hair growth. Minoxidil by getting converted to​ minoxidil sulfate enhances potassium ion permeability to​ prevent calcium ions from entering into cells. it​ takes about few months time for​ the​ results to​ be evident since it​ is​ the​ time which is​ necessary for​ restoring the​ normal growth cycle of​ hair fibers.
Though minoxidil does not have any effect on​ blood pressure,​ it​ should be used with caution in​ patient with cardiovascular diseases. it​ is​ also contraindicated in​ pregnant and nursing mothers.
The ​Drug​ finasteride was earlier used as​ treatment for​ prostate enlargement,​ under the​ medical name Proscar. But in​ 1998,​ it​ was approved by FDA for​ the​ Medical hair loss restoration in​ MPHL.
Mechanism of​ Action
Medical hair restoration treatments with Finasteride depends upon its specific action as​ an inhibitor of​ type II 5αreductase,​ the​ intracellular enzyme that converts male hormone androgen into DHT Dihydro Testosterone. Its action results in​ significant decrease in​ serum and tissue DHT levels in​ even in​ concentration as​ low as​ 0. 2mg. Finasteride stabilizes hair loss in​ 80% of​ patient with Vertex hair loss and in​ 70% of​ patients with frontal hair loss. the​ peculiar thing about Propecia is​ that its effect is​ more pronounced in​ crown area than in​ the​ front.
Many hair restoration surgeons find Propecia finasteride to​ act as​ an excellent adjunct to​ the​ surgical hair restoration.
Combination Therapy
There are reports which say that use of​ finasteride and topical minoxidil combination therapy as​ a​ Medical hair restoration treatment is​ of​ more advantage in​ cases of​ mild to​ moderate MPHL. Many hair restoration doctors have already started the​ use of​ combination therapy in​ order to​ obtain better hair growth.
Anti Androgen Therapy
For women with hyperandrogonismwith increased levels of​ androgen who do not respond well to​ minoxidil,​ antiandrogen therapy is​ another option of​ medical hair restoration. in​ UK the​ most commonly used antiandrogen for​ women is​ CPA cyproterone acetate,​ which is​ used in​ combination with ethinylestradiol.
In United States CPA is​ not available,​ the​ aldosterone antagonist spironolactone is​ the​ alternative choice of​ hair restoration doctors.
Medical hair restoration with flutamide has shown improvement as​ hair loss restoration treatment in​ women with hirsutism. for​ hyperandrogenic premenopausal women,​ flutamide is​ a​ better medical hair restoration agent than both the​ CPA or​ finestride.
Hair loss restoration management is​ a​ structured process. for​ more details on​ the​ topic you​ can refer to​ section medical hair restoration or​ article on​ male pattern hair loss or​ female pattern hair loss at​ our site hairtransplantadvice. com.

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