Side Effects And Information About Steroids And Supplements

Side Effects And Information About Steroids And Supplements



This drug is​ unique (so far as​ I know) in​ that 5a -reductase, the enzyme which converts testosterone to​ the more-potent DHT, actually converts nandrolone to​ a​ less-potent compound. Therefore this AAS is​ somewhat deactivated in​ the skin, scalp, and prostate, and these tissues experience an​ effectively-lower androgen level than the rest of​ the body. Therefore, for the same amount of​ activity as​ another drug at​ the androgen
receptors (ARs) in​ muscle tissue, Deca gives less activity in​ the scalp, skin, and prostate. Thus, it​ is​ the best choice for those particularly concerned with these things. Its effectiveness at​ the androgen receptor of​ muscle tissue is​ superior to​ that of​ testosterone: it​ binds better. Yet, it​ gives only about half the muscle-building results per milligram. This I think is​ a​ result of​ its being less effective or​ entirely ineffective in​ non-AR-mediated mechanisms for muscle growth.

It also appears less effective or​ entirely ineffective in​ activity on nerve cells, certainly on the nerve cells responsible for erectile function. Use of​ Deca as​ the sole AAS often results in​ complete inability to​ perform sexually. These problems can be solved by combining with a​ drug that does supply the missing activity: e.g. testosterone.

Nandrolone is​ proven to​ be a​ progestin. This fact is​ of​ clear importance in​ bodybuilding, because while moderate Deca-only use actually lowers estrogen levels as​ a​ consequence of​ reducing natural testosterone levels and thus allowing the aromatase enzyme less substrate to​ work with, Deca nonetheless can cause gyno in​ some individuals. Furthermore, just as​ progesterone will to​ a​ point increase sex drive in​ women, and then often decrease it​ as​ levels get too high, high levels of​ progestogenic steroids can kill sex drive in​ male bodybuilders, though there is​ a​ great deal of​ individual variability as​ to​ what is​ too much.

Incidentally, this progestogenic activity also inhibits LH production, and contrary to​ common belief, even small amounts of​ Deca are quite inhibitory, approximately as​ much so as​ the same amount of​ testosterone. to​ some extent, nandrolone aromatizes to​ estrogen, and it​ does not appear that this can be entirely blocked by use of​ aromatase inhibitors – indeed, aromatase may not be involved at​ all in​ this process (there is​ no
evidence in​ humans that such occurs) with the enzyme CYP 2C11 being in​ my
opinion the more likely candidate for this activity. in​ any case, Cytadren, an​ aromatase
inhibitor, has not been found effective in​ avoiding aromatization of​ nandrolone.

The drug is​ moderately effective at​ doses of​ 400 mg/week. The long half-life of​ nandrolone decanoate makes it​ unsuited to​ short alternating cycles, but suitable for more traditional cycles, with a​ built-in self-tapering effect in​ the weeks following the last injection.

Trivial name Nandrolone
Systematic name Estr-4-en-3-one, 17-beta-hydroxy-
CAS registry number 434-22-0
ATC code A14AB01
Merck Index Number 6391
Chemical formula C18H26O2
Molecular weight 274.401 g/mol
100% (Intramuscular)
Metabolism Hepatic
Elimination half-life 6 days
Excretion Undocumented
Pregnancy category X
Routes of​ administration Intramuscular




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