New Test For Breast Cancer Making Individualized Treatment Decisions A
Reality

New Test For Breast Cancer Making Individualized Treatment Decisions A Reality



Widely hailed as​ the​ next frontier in​ medical advances, the​ promise of​ individualized medicine is​ becoming a​ reality thanks to​ progress in​ understanding the​ molecular basis of​ diseases such as​ breast cancer. Scientists can now develop treatments that are tailored to​ individual genetic profiles, as​ well as​ tests to​ predict how a​ patient will respond to​ existing therapies.

Today, some women with early-stage breast cancer and​ their physicians can make more informed treatment decisions with the​ Oncotype DX Breast Cancer Assay. This service provides quantitative information about genes from a​ woman's individual tumor to​ generate a​ Recurrence Score between zero and​ 100, indicating whether she is​ at​ high, intermediate or​ low risk for​ her cancer returning after treatment.

Oncotype DX is​ intended for​ patients with node-negative, estrogen receptor-positive breast cancer who are likely to​ be treated with hormonal therapy. Approximately half of​ the​ 230,000 patients diagnosed with breast cancer in​ the​ United States each year fall into this category, and​ are frequently offered treatment with chemotherapy, a​ widely used treatment with considerable side effects. Clinical studies show that chemotherapy improved patient survival rates in​ only 4 out of​ 100 patients, yet thousands of​ women continue to​ elect this costly and​ toxic treatment with only limited information about whether they might respond to​ it.

A recent study demonstrated that women with high Recurrence Scores are more likely to​ benefit from chemotherapy, whereas women with lower scores derive only minimal benefit. Further, only 25% of​ women fell into the​ high-risk group, compared to​ 50% in​ the​ low-risk group, indicating that this common treatment is​ not appropriate for​ every patient.

Elizabeth Sloan of​ New York City is​ one of​ the​ many breast cancer patients not likely to​ respond to​ chemotherapy. an​ active mother with two young boys, Elizabeth was considering having another child when she was diagnosed at​ just 40 years old. She wanted to​ avoid chemotherapy, with its disruptive, short-term side effects and​ potentially serious long-term implications, but also wanted to​ be absolutely certain that it​ wouldn't help her.

Working with her doctor, Ruth Oratz, M.D., at​ NYU Medical Center, Elizabeth decided to​ have the​ Oncotype DX assay, and​ was delighted when her Recurrence Score turned out to​ be low-indicating that she may not benefit significantly from chemotherapy.

"No two women with breast cancer are exactly alike. Oncotype DX provides information that goes beyond standard measures, like age, tumor size and​ tumor grade, in​ determining the​ likelihood of​ disease recurrence," says Dr. Oratz. "Oncotype DX gave Elizabeth and​ me added confidence and​ peace of​ mind in​ selecting the​ most fitting treatment for​ her."

For Susan Bakken of​ Denver, Colorado, Oncotype DX provided a​ different kind of​ peace of​ mind. Susan's Recurrence Score indicated that she was at​ high risk of​ cancer recurrence, and​ would likely benefit significantly from chemotherapy-to both her surprise and​ her doctor's.

"Based on the​ other tests I had, my doctor said he wouldn't have otherwise recommended chemotherapy. I was shocked to​ find out my result, but I was so glad I did because I believe this test basically saved my life," explained Susan.

Elizabeth Sloan is​ also grateful for​ the​ information she gained from Oncotype DX. "Not all cancers are the​ same, so why treat everyone the​ same way with something so toxic?" she said. "It's so remarkable that finally, doctors can distinguish one person's cancer from another-I'm just so thankful."

Oncotype DX is​ a​ simple test that can only be ordered by a​ physician. it​ is​ performed on a​ small amount of​ breast tumor tissue removed during a​ standard lumpectomy, mastectomy or​ biopsy, meaning no additional procedure is​ required.




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