Coffee May Reduce Liver Cancer Risk

Coffee May Reduce Liver Cancer Risk

March 31, 2018, Milan — a​ recent study conducted by the​ researchers of​ Istituto di Ricerche Farmacologiche Mario Negri (IRFMN) in​ Milan, Italy showed that drinking coffee may help reduce the​ risk of​ liver cancer. Led by Francesca Bravi, the​ team combined all published data to​ find the​ link between coffee drinking and​ hepatocellar carcinoma (HCC). HCC is​ a​ primary cancer of​ the​ liver. Liver cancer is​ the​ third largest cause of​ cancer deaths around the​ world, just behind lung and​ stomach cancer. at​ least 11 studies that were conducted in​ southern Europe and​ Japan were the​ foundation of​ the​ IRFMN study.
The IRFMN study was a​ meta-analysis of​ published studies on HCC that included how much coffee patients had consumed. Researchers combined all published data to​ obtain an​ overall quantitative estimate of​ the​ association between coffee consumption and​ HCC development.
The figures showed that coffee drinkers have at​ least 41 percent reduction of​ HCC risk compared to​ those who never consumed coffee. the​ beneficial effects of​ coffee consumption were highly progressive in​ studies that were done in​ southern Europe, widely drank, and​ from Japan, where coffee drinking is​ less frequent, and​ in​ subjects with chronic liver diseases
Animal and​ laboratory studies have shown that some compounds in​ coffee may act as​ blocking agents that work by reacting with enzymes involved in​ carcinogenic detoxification. Caffeine is​ a​ component of​ coffee that has been shown to​ give beneficial effects on the​ liver enzymes and​ other enzymes of​ the​ body. Coffee consumption has also been linked to​ reduced risks of​ liver diseases and​ cirrhosis, both of​ which can lead to​ liver cancer.
Separate studies also show that caffeine may aggravate the​ symptoms of​ menopause or​ intensify the​ effects of​ certain antibiotics. On the​ other hand, heavy caffeine consumption may cause miscarriage. Other animal studies show that skin cream added with caffeine may lower the​ risk of​ skin cancer in​ mice.
While the​ study found a​ statistically significant relationship between drinking coffee and​ having less liver cancer, the​ authors note that it​ needs to​ be repeated in​ other groups. the​ authors note that despite the​ consistency of​ the​ results of​ the​ study, it​ is​ difficult to​ derive causal collaboration based on the​ observational studies alone. it​ may be that patients with digestive tract diseases, including liver disorders, naturally reduce their coffee consumption, even though avoidance of​ coffee is​ not routinely recommended.
While the​ study found a​ statistically significant relationship between drinking coffee and​ having less liver cancer, the​ authors note that it​ needs to​ be repeated in​ other groups to​ be more concrete.
The IRFMN researchers note that the​ perception of​ coffee consumption was solely based on patients’ reporting, although the​ recollection of​ coffee drinking has been shown to​ be accurate. Factors like hepatitis B and​ C, cirrhosis, social class indictors, alcohol use, and​ smoking suggests that these factors did not influence the​ results of​ the​ studies.
The results from this research may provide some evidence of​ a​ link between coffee consumption and​ liver cancer. However, the​ interpretation of​ this research remains unclear because of​ lack of​ long-term evaluation of​ the​ results of​ the​ said study.

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