A Step Closer To Drug Addiction And Phobia Treatment

A Step Closer To Drug Addiction And Phobia Treatment



A Step Closer to ​Drug​ Addiction and​ ​ Phobia Treatment
Scientists are now looking into solving ​Drug​ abuse cases by studying on a​ certain medication that could possibly be the​ most effective ​Drug​ for​ treating addiction. ​
This specific ​Drug​ is​ also known to control phobias. ​
The US Department of​ Energys Brookhaven National Laboratory provides further evidence that a​ ​Drug​ known as​ D cycloserine could play a​ role in helping to extinguish the​ craving behaviors associated with ​Drug​ abuse, or​ specifically, with the​ addiction to psychotropic ​Drug​s. ​
Their study found that mice treated with Dcycloserine were less likely to spend time in an environment where they had previously been trained to expect cocaine than mice treated with a​ placebo.
A graduate student from Stony Brook University working under Brookhaven Laboratory, Carlos Bermeo said that since the​ association between ​Drug​s and​ ​ the​ places where they are used can trigger craving and/or relapse in humans, a​ medication that could aid in the​ reduction or​ even extinction of​ such responses could be a​ powerful tool in the​ treatment of​ addiction.
The Dcycloserine was originally developed as​ an antibiotic. ​
But this ​Drug​ has also shown to extinguish conditioned fear in preclinical animal studies, and​ ​ has been successfully tested in human clinical trials for​ the​ treatment of​ acrophobia or​ fear of​ heights. ​
This finding led the​ researchers to wonder whether Dcycloserine could extinguish ​Drug​ seeking behaviors as​ well. ​
Last 2018, a​ group of​ scientists not associated with the​ Brookhaven Lab tested this hypothesis in rats. ​
They found out that Dcycloserine facilitated the​ extinction of​ cocaine conditioned place reference in which the​ tendency for​ the​ animals to spend more time in a​ chamber where they had been trained to expect cocaine than in a​ chamber where they had no access to the​ ​Drug​ whatsoever. ​
This study builds on the​ previous work and​ ​ adds information on the​ ​Drug​ dose effect, the​ lasting properties of​ the​ treatment, and​ ​ the​ locomotor effects of​ this compound.
In the​ study, the​ group worked with C57bL/c mice. ​
The animals were first trained to receive cocaine in a​ specific environment. ​
Once conditioned, place preference was established animals willingly spent more time in a​ cocainepaired environment than in a​ neutral environment, the​ mice were treated with either Dcycloserine or​ saline and​ ​ were allowed to spend forty minutes in either the​ previously cocainepaired environment in which the​ ​Drug​ was no longer available, or​ the​ neutral environment. ​
According to one of​ their researchers, this paradigm would be analogous to a​ clinical approach where the​ addict is​ returned to their natural environment where ​Drug​ use was done, but this time with no ​Drug​ available. ​
He added that reduced seeking of​ the​ ​Drug​ in the​ same environment—that is​ the​ extinction behavior—is a​ great indicator of​ future success in treatment and​ ​ reduced chance of​ relapse.
However, these researchers said that it​ is​ important to remember that these are very preliminary results from a​ small animal study, and​ ​ much further research will be required before testing this ​Drug​ in humans. ​
Nonetheless, it​ is​ inspiring to know that this ​Drug​ may show promise in treating cocaine addiction that continues to take a​ toll on society and​ ​ for​ which no pharmacological treatment currently exists. ​
Such research studies would take us a​ step closer in treating phobias, as​ well as​ ​Drug​ abuse.




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